Blog Post

The 411 on Neffy (The First Nasal Spray Form of Epinephrine)

This past summer, the FDA approved Neffy, the first nasal spray version of epinephrine.1 Epinephrine is used for the treatment of severe allergic reactions (such as anaphylaxis). Signs of a severe allergic reaction include:

  • Hives
  • Swelling of the face, lips, tongue and/or throat
  • Throat closing
  • Hoarseness and difficulty speaking in complete sentences
  • Trouble breathing
  • Vomiting and diarrhea
  • Dizziness and possible fainting
  • Confusion and/or anxiety
  • Low blood pressure and a rapid weak pulse

Epinephrine is a potentially life-saving medicine that can reverse these effects.

Here are 5 Things to Know About Neffy…

1. Neffy is approved for the emergency treatment of life-threatening allergic reactions in adults & children weighing at least 66 pounds.2

2. Until Neffy was created, the only portable, self-administered forms of epinephrine were auto-injectors (like EpiPen and AUVI-Q), which rely on a needle to deliver the medication. Neffy represents the first needle-free option for delivering epinephrine.

3. Each Neffy device delivers a single dose of 2 milligrams (mg) of epinephrine. If symptoms persist (or worsen), a second dose may be administered in the same nostril with a new Neffy device starting 5 minutes after the first dose. Proper training on the use of Neffy is essential.

4. Neffy needs to be stored at room temperature and protected from sunlight.

5. Studies show that Neffy works just as well as the traditional needle-based auto-injectors.3

Common Question: Has Neffy Hit the Market Yet?

Yes! Neffy is now available by prescription across the United States. The cost depends on patients’ insurance coverage and eligibility for assistance programs. For those with insurance, the out-of-pocket cost may be as low as $25. Patients without insurance can purchase a 2-pack of single-use devices for $199.

The Bottom Line

Neffy offers a promising needle-free alternative to traditional forms of epinephrine and could become a game-changer for kids & adults with severe allergies. If you or your child has severe allergies, ask the doctor if Neffy is a good option for you.


Footnotes

1. U.S. Food and Drug Administration (FDA). August 2024. “FDA Approves First Nasal Spray for Treatment of Anaphylaxis.” https://www.fda.gov/news-events/press-announcements/fda-approves-first-nasal-spray-treatment-anaphylaxis.
[Accessed November, 2024]
2. American Academy of Pediatrics (AAP) News. August 2024. “FDA Approves First Nasal Spray to Treat Anaphylaxis.”  https://publications.aap.org/aapnews/news/29632/FDA-approves-first-nasal-spray-to-treat.
[Accessed November, 2024]

3. ARS Pharmaceuticals. September 2024. “Single and Repeat Dose Clinical Study of Neffy Epinephrine Nasal Spray Demonstrates Comparable Effectiveness to Intramuscular Injection.”
https://ir.ars-pharma.com/news-releases/news-release-details/single-and-repeat-dose-clinical-study-neffy-epinephrine-nasal.
[Accessed November, 2024]

Content
1. Journal of Allergy and Clinical Immunology. October 2024. “Neffy, Epinephrine Nasal Spray, Demonstrates a Positive Efficacy and Safety Profile.” https://www.jacionline.org/article/S0091-6749(23)02379-5/fulltext.

[Accessed November, 2024]
2. Everyday Health. August 2024. “FDA Approves the First Nasal Spray for Severe Allergic Reactions.”  https://www.everydayhealth.com/allergies/fda-approves-first-nasal-spray-for-severe-allergic-reactions/.
[Accessed November, 2024]
3. BMJ (British Medical Journal). September 2024. “US Approves First Nasal Spray for Anaphylaxis.”
https://www.bmj.com/content/386/bmj.q1789.
[Accessed November, 2024]
4. MedEd 101. September 2024. “Neffy Versus EpiPen: Clinical Comparison.” https://www.meded101.com/neffy-versus-epipen-clinical-comparison/
[Accessed November, 2024]
5. T. B. Casale et al., “Single and Repeat Dose Clinical Study of Neffy (Epinephrine Nasal Spray) Published in the Journal of Allergy and Clinical Immunology,” Journal of Allergy and Clinical Immunology 152, no. 4 (2023): 789–798, https://www.jacionline.org/article/S0091-6749(23)02379-5/fulltext.
[Accessed November, 2024]

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Dr. Blair Farr is a board-certified doctor and Mom of two. Her goal is to use her personal & professional experiences to help others find more support, peace, and joy on their own pregnancy & parenting journeys.